2017 Wylie Scholar
Assistant Professor of Surgery
Vascular Surgery Section
Washington University School of Medicine
Dr. Sean English became the 20th Wylie Scholar for his research project to neutralize the body’s signaling mechanisms which cause abdominal aortic aneurysms (AAA).
Abdominal aortic aneurysm (AAA) represents an important medical and surgical disease process, and AAA rupture carries significant morbidity and mortality. Without an accepted medical therapy, current surgical approaches, and need for long-term follow-up imaging, related outcomes carry increasing financial implications. Diagnostic and surveillance modalities utilized for the assessment of AAAs are limited. The inflammation associated with AAA development is multifaceted; however, we have identified a particular signaling molecule that plays an integral role in both AAA development and rupture. We intend to assess the ability of a positron emission tomography (PET) radiotracer to neutralize this signaling molecule, in an effort to limit AAA development and decrease associated rupture, while at the same time demonstrating inflammation predictive of growth/rupture in an animal model that we developed, also referred to as theranostics. For the first time in patients, we will also evaluate the ability of this radiotracer to noninvasively characterize human AAA associated inflammation.
Dr. English is the 3rd Wylie Scholar from Washington University, a testament to the program’s commitment to career mentorship.